Perioperative Use of Diluted Hydrogen Peroxide During Convexity Meningioma Resection: A Retrospective Observational Study

Abstract

Objective:  Convexity meningiomas are the most common extra-axial brain tumors and can be challenging to remove due to high vascularity. Hydrogen peroxide has historically been used in neurosurgical procedures because of its oxidizing and hemostatic properties; however, evidence regarding its role in convexity meningioma surgery remains limited. The study aimed to evaluate the feasibility and perioperative outcomes associated with the use of diluted hydrogen peroxide during convexity meningioma surgery.

Materials & Methods:  This retrospective study included 86 patients who underwent convexity meningioma surgery at the Ali Institute of Neurosciences from January 2017 to March 2022. Diluted hydrogen peroxide was applied during surgery to alter tumor consistency, control bleeding, and reduce tumor blood supply. Patient demographics, clinical features, and surgical outcomes were analyzed descriptively.

Results:  There were 42 males (48.8%) and 44 females (51.2%) with a mean age of 56.3 years. Headache was the most common symptom (72.1%). Gross total resection was achieved in 78 cases (90.7%), with minimal bleeding in most patients. Perioperative complications occurred in 12 cases (13.9%).

Conclusion:  The use of perioperative diluted hydrogen peroxide during convexity meningioma surgery appeared feasible and was associated with acceptable surgical outcomes in this retrospective series. However, due to the absence of a control group, definitive conclusions regarding superiority or direct effects on bleeding reduction and tumor resection cannot be established.

Keywords:  Convexity meningioma, hydrogen peroxide, outcomes, peri-operative complication, surgical resection.