Targeting cytokine- therapy to alleviate neuropathic pain caused by the spinal damage


  • Saman Shahid National University of Computer & Emerging Sciences -NUCES, FAST Lahore
  • Muhammad Anwar Chaudary Chief Editor, Ex-Head of Department Neurosurgery Unit II, (PINS), Department of Neurosurgery, Farooq Hospital, Lahore – Pakistan



C – Spine injuries


Allison DJ, Thomas A, Beaudry K, Ditor DS. Targeting inflammation as a treatment modality for neuropathic pain in spinal cord injury: a randomized clinical trial. Journal of neuroinflammation. 2016;13:1-0.

Iwatsuki K, Arai T, Ota H, Kato S, Natsume T, Kurimoto S, Yamamoto M, Hirata H. Targeting anti-inflammatory treatment can ameliorate injury-induced neuropathic pain. PLoS One. 2013;8(2):e57721.

Park J, Decker JT, Smith DR, Cummings BJ, Anderson AJ, Shea LD. Reducing inflammation through delivery of lentivirus encoding for anti-inflammatory cytokines attenuates neuropathic pain after spinal cord injury. Journal of controlled release. 2018;290:88-101.

Hung AL, Lim M, Doshi TL. Targeting cytokines for treatment of neuropathic pain. Scandinavian journal of pain. 2017 Oct 1;17(1):287-93.

Chio JC, Xu KJ, Popovich P, David S, Fehlings MG. Neuroimmunological therapies for treating spinal cord injury: Evidence and future perspectives. Experimental Neurology. 2021;341:113704.

Hagen EM, Rekand T. Management of neuropathic pain associated with spinal cord injury. Pain and therapy. 2015;4:51-65.

Roselli F, Chandrasekar A, Morganti-Kossmann MC. Interferons in traumatic brain and spinal cord injury: current evidence for translational application. Frontiers in neurology. 2018;9:388683.