Controlled Decompression Effects in Patients with Severe Traumatic Brain Injury: A Randomized Controlled Trial
DOI:
https://doi.org/10.36552/pjns.v29i3.922Abstract
Objective: To investigate whether controlled decompression therapy reduces the incidence of comorbidities and enhances recovery in sTBI patients.
Materials and Methods: In a Khyber teaching hospital, sTBI patients aged 18 to 75 years were randomly divided into one of two groups: controlled decompression (CD) surgery (n = 26) and fast decompression surgery (n = 26) in a randomized control experiment. The primary outcome markers were 30-day all-cause mortality and the Extended-Glasgow Outcome-Scale (GOS-E) score at six months. Secondary outcomes included delayed bleeding, posttraumatic brain infarction, and intraoperative brain infarction.
Results: The greatest improvement in six-month GOS-E score was a remarkable reduction in 30-day all-cause mortality in the controlled decompression (CD) group in comparison to the group fast decompression group of the participants (15.3% compared with 24.6%, a P value of -0.042). Additionally, subjects in the group of supervised decompression surgery had lower intraoperative brain edema (19.2% versus 42.3%, p-value 0.033), late bleeding (11.5% versus 30.7%, p-value 0.048), and cerebral infarction after trauma than the rapid decompression group (15.0% versus 22.4%, with a p-value less than 0.001).
Conclusion: Controlled decompression (CD) surgical interventions have been found to significantly uplift the outcomes for individuals with severe traumatic brain injury (sTBI) and reduce the likelihood of related health conditions so but a more comprehensive understanding of the importance of standardized directed decompression surgical intervention in the management of sTBI requires multicenter randomized controlled trials.
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Copyright (c) 2024 Dr. Abdul Hameed Khan, Mahboob Khan, Dr. Farooq Sherzada, Dr. Abdul Basit Khan, Dr. Laila Ghaffar, Dr. Nayyab OrakzaiThe work published by PJNS is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Copyrights on any open access article published by Pakistan Journal of Neurological Surgery are retained by the author(s).
